Purine ribonucleotide salvage

Across TCGA cell cohorts, RNA activity of the Purine ribonucleotide salvage pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGR2, SNTA1, and FXYD3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGR2 grouped by Purine ribonucleotide salvage-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AGR2 →	+3.120	+0.557	<.001	.002	3	5
LUNG_NSCLC_LUAD	SNTA1 →	-0.991	-0.583	.002	.009	3	5
LUNG_NSCLC_LUAD	FXYD3 →	+2.500	+0.696	.003	<.001	3	5
LUNG_SCLC	IRF6 →	+3.364	+0.280	<.001	.006	2	6
STOMACH	SYDE1 →	-2.517	-0.934	.001	.008	2	5
STOMACH	TMEM87B →	+1.603	+1.087	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGR2 by Purine ribonucleotide salvage activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →