tRNA surveillance

Across TCGA patient cohorts, RNA activity of the tRNA surveillance pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF367, ASPM, and SENP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA surveillance activity versus ZNF367 in BRCA (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF367 →	+0.852	+0.175	<.001	<.001	3	4
GBM	ASPM →	+0.921	+0.118	.002	.007	3	4
UCEC	SENP1 →	+0.322	+0.176	.007	.001	3	4
GBM	XPA →	+0.267	+0.114	.009	.006	3	4
GBM	DIAPH3 →	+0.644	+0.168	.005	<.001	3	4
GBM	CIP2A →	+0.540	+0.149	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106354 vs ZNF367 — BRCA

Explore this scatter interactively →