Protein-DNA covalent cross-linking repair

Across TCGA patient cohorts, RNA activity of the Protein-DNA covalent cross-linking repair pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IPO9, RPRD2, and RRP36_S73, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein-DNA covalent cross-linking repair activity versus IPO9 in GBM (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	IPO9 →	+0.267	+0.060	.006	<.001	3	9
LSCC	RPRD2 →	+0.324	+0.076	<.001	<.001	3	9
GBM	RRP36_S73 →	+0.784	+0.076	<.001	<.001	3	8
GBM	SMARCC1 →	+0.422	+0.064	<.001	<.001	3	8
LSCC	C1orf35 →	+0.574	+0.094	<.001	<.001	3	8
COAD	CIP2A →	+0.560	+0.035	<.001	.003	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106300 vs IPO9 — GBM

Explore this scatter interactively →