Protein-DNA covalent cross-linking repair

Across TCGA cell cohorts, RNA activity of the Protein-DNA covalent cross-linking repair pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITPRIPL1, ZFAND1, and ELF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITPRIPL1 grouped by Protein-DNA covalent cross-linking repair-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ITPRIPL1 →	-2.234	-0.265	.003	.002	3	3
STOMACH	ZFAND1 →	+0.871	+0.205	.002	.007	3	3
STOMACH	ELF2 →	+0.452	+0.243	.003	<.001	3	3
LIVER	TOMM5 →	-0.815	-0.182	<.001	.001	3	3
STOMACH	DPP3 →	-0.762	-0.271	<.001	.002	3	3
KIDNEY	VCP →	-0.692	-0.220	.001	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITPRIPL1 by Protein-DNA covalent cross-linking repair activity — SOFT_TISSUE

Explore this box plot interactively →