Regulation of glutamate receptor clustering

Across TCGA patient cohorts, RNA activity of the Regulation of glutamate receptor clustering pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MTHFD2, RELCH_S244, and S100A12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glutamate receptor clustering activity versus MTHFD2 in LUAD (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTHFD2 →	+0.464	+0.100	<.001	<.001	3	6
LUAD	RELCH_S244 →	+0.454	+0.145	<.001	<.001	3	6
PDAC	S100A12 →	+1.141	+0.120	.002	<.001	3	5
LUAD	KIF21A_S1212 →	+0.367	+0.107	.002	<.001	3	5
PDAC	LARP4_S583 →	+0.430	+0.131	<.001	<.001	3	5
PDAC	MMP9 →	+0.787	+0.091	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106104 vs MTHFD2 — LUAD

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