Regulation of glutamate receptor clustering

Across TCGA cell cohorts, RNA activity of the Regulation of glutamate receptor clustering pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMIM14, ZNF703, and PCIF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMIM14 grouped by Regulation of glutamate receptor clustering-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SMIM14 →	+1.666	+1.175	.001	.002	3	5
BLOOD_Leukemia	ZNF703 →	+1.574	+1.499	<.001	.001	3	5
CNS	PCIF1 →	+0.760	+1.227	<.001	.002	3	5
OVARY	NSA2 →	-0.908	-1.276	.002	.002	2	5
BLOOD_Leukemia	MICAL1 →	+2.575	+1.405	<.001	<.001	3	4
BLOOD_Leukemia	CAPN3 →	+2.262	+1.608	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMIM14 by Regulation of glutamate receptor clustering activity — LUNG_SCLC

Explore this box plot interactively →