Aminoacyl-tRNA metabolism involved in translational fidelity

Across TCGA patient cohorts, RNA activity of the Aminoacyl-tRNA metabolism involved in translational fidelity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIPK3, IFTAP, and MIR378E, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Aminoacyl-tRNA metabolism involved in translational fidelity activity versus HIPK3 in GBM (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HIPK3 →	-0.282	-0.090	.007	.004	3	4
HNSC	IFTAP →	-0.257	-0.117	.006	.002	2	5
LSCC	MIR378E →	-1.141	-0.204	<.001	.003	3	4
CCRCC	CCDC28A →	-0.267	-0.117	<.001	.001	3	4
OV	APOL4 →	-1.377	-0.130	<.001	.005	3	3
GBM	TMEM60 →	+0.266	+0.124	.008	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106074 vs HIPK3 — GBM

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