Aminoacyl-tRNA metabolism involved in translational fidelity

Across TCGA cell cohorts, RNA activity of the Aminoacyl-tRNA metabolism involved in translational fidelity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP49, BAG6, and RNF5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP49 grouped by Aminoacyl-tRNA metabolism involved in translational fidelity-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	USP49 →	-0.835	-0.194	.005	.001	3	4
LUNG_SCLC	BAG6 →	-0.472	-0.199	.006	.001	3	4
SOFT_TISSUE	RNF5 →	-0.436	-0.235	.004	.004	2	5
LUNG_NSCLC_LUSC	PORCN →	+1.928	+0.210	.009	.002	3	4
PANCREAS	ZBTB12 →	-0.978	-0.184	.002	.002	3	4
PANCREAS	NFKBIL1 →	-0.883	-0.192	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP49 by Aminoacyl-tRNA metabolism involved in translational fidelity activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →