Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PDE4B, CRTC3, and HERC1, each associated with the pathway in up to 22 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway activity versus PDE4B in UCS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	PDE4B →	+1.341	+0.082	<.001	<.001	3	22
DLBC	CRTC3 →	+1.366	+0.065	.001	.001	3	21
TGCT	HERC1 →	+0.768	+0.047	<.001	<.001	3	20
MESO	FAM102B →	+0.738	+0.038	.001	.003	3	20
UCS	MEF2A →	+1.001	+0.069	.002	.002	2	21
TGCT	PIAS1 →	+0.781	+0.050	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106072 vs PDE4B — UCS

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