Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CSE1L, DDX41, and DIS3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway activity versus CSE1L in LSCC (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CSE1L →	-0.303	-0.088	.005	<.001	3	6
GBM	DDX41 →	-0.210	-0.080	.005	<.001	3	6
HNSC	DIS3 →	-0.269	-0.065	<.001	.002	3	5
COAD	UTP15 →	-0.234	-0.044	<.001	<.001	3	5
GBM	CAD →	-0.204	-0.043	<.001	.004	3	5
CCRCC	FLI1_S241 →	+0.501	+0.075	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106072 vs CSE1L — LSCC

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