Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARD14, SLC9A3R1, and ATP10D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway activity versus CARD14 in BREAST (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CARD14 →	-2.292	-1.007	<.001	.001	3	4
BREAST	SLC9A3R1 →	-4.372	-1.797	<.001	<.001	3	3
BREAST	ATP10D →	+1.324	+0.907	.008	.006	3	3
BREAST	DZIP1L →	+2.100	+1.301	.001	.001	3	3
LUNG_NSCLC_LUAD	NAA80 →	+0.624	+0.772	.003	.006	3	3
KIDNEY	GADD45G →	-1.039	-0.129	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106072 vs CARD14 — BREAST

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