Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEBPZ, MAP1A_S612, and PRKCA_S226, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway activity versus CEBPZ in GBM (Pearson r = -0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CEBPZ →	-0.222	-0.054	.005	.002	3	5
LSCC	MAP1A_S612 →	+1.338	+0.080	.002	<.001	3	5
LSCC	PRKCA_S226 →	+0.540	+0.067	<.001	<.001	3	5
GBM	CMTR2 →	-0.221	-0.065	.001	<.001	3	4
OV	ATL1_S10 →	+0.661	+0.048	.002	.005	3	4
UCEC	HTT →	-0.170	-0.072	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106070 vs CEBPZ — GBM

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