Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF2C, KIF18B, and TROAP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway activity versus KIF2C in UCEC (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF2C →	-0.771	-0.347	.005	.003	3	4
UCEC	KIF18B →	-0.602	-0.272	.002	.003	3	4
CCRCC	TROAP →	-0.321	-0.278	.005	.001	3	4
CCRCC	MKI67 →	-0.477	-0.289	.007	<.001	3	4
PDAC	RNU7-154P →	+0.857	+0.597	.007	<.001	3	4
PDAC	WDR62 →	-0.336	-0.401	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106070 vs KIF2C — UCEC

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