Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A45, DMPK, and RETSAT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC25A45 grouped by Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC25A45 →	-1.284	-0.241	<.001	<.001	3	4
BLOOD_Lymphoma	DMPK →	-2.410	-0.661	.008	.002	3	4
BLOOD_Lymphoma	RETSAT →	-0.872	-0.497	<.001	.002	3	4
LARGE_INTESTINE	ALG5 →	+0.521	+0.166	.007	.001	3	3
OESOPHAGUS	OR7C1 →	-0.101	-0.199	.006	.003	3	3
LARGE_INTESTINE	TLE3 →	-0.807	-0.187	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC25A45 by Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway activity — OESOPHAGUS

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