Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYT12, IRX3, and ZNF672, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYT12 grouped by Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SYT12 →	+0.078	+0.088	.007	.003	3	4
BLOOD_Myeloma	IRX3 →	-0.389	-0.103	<.001	<.001	3	4
LUNG_SCLC	ZNF672 →	-0.235	-0.163	.002	.006	3	4
KIDNEY	CIT →	-0.159	-0.178	.001	.002	3	4
SOFT_TISSUE	CENPT →	-0.567	-0.213	<.001	.002	3	4
SOFT_TISSUE	UBTF →	+0.199	+0.159	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYT12 by Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway activity — LUNG_NSCLC_LUAD

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