Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI2, DRAP1, and FLNA, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway activity versus GNAI2 in OVARY (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	GNAI2 →	+1.381	+0.301	<.001	<.001	3	10
OVARY	DRAP1 →	+1.109	+0.250	.001	.001	3	6
LUNG_NSCLC_LUAD	FLNA →	+1.106	+0.198	<.001	.001	3	6
SKIN	RASSF1 →	+0.869	+0.132	<.001	.005	3	6
CNS	SNX15 →	+0.725	+0.131	.002	<.001	3	5
LARGE_INTESTINE	PPP1R18 →	+2.147	+0.369	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106070 vs GNAI2 — OVARY

Explore this scatter interactively →