Positive regulation of calcineurin-mediated signaling

Across TCGA cell cohorts, RNA activity of the Positive regulation of calcineurin-mediated signaling pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOMM20, HDHD5, and EPS8L1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of calcineurin-mediated signaling activity versus TOMM20 in BREAST (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TOMM20 →	+0.460	+0.115	.003	.005	3	4
SKIN	HDHD5 →	-0.728	-0.189	<.001	.001	3	4
SKIN	EPS8L1 →	+0.921	+0.154	.005	.009	3	4
STOMACH	VIPAS39 →	-0.872	-0.288	.003	.007	3	4
LIVER	ABCD1 →	-1.582	-0.214	.003	.001	3	3
LIVER	ANKEF1 →	-0.758	-0.224	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106058 vs TOMM20 — BREAST

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