Regulation of cellular response to osmotic stress

Across TCGA patient cohorts, RNA activity of the Regulation of cellular response to osmotic stress pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLAT, C4BPA, and ZNF451_S1027, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to osmotic stress activity versus PLAT in UCEC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PLAT →	+0.667	+0.051	.001	.009	3	5
GBM	C4BPA →	+0.621	+0.084	<.001	.002	3	5
CCRCC	ZNF451_S1027 →	-0.355	-0.096	.001	<.001	3	4
GBM	CDK12_S1083 →	-0.389	-0.098	<.001	<.001	3	4
GBM	EFHD1 →	+0.788	+0.111	<.001	<.001	3	4
LSCC	RFLNB →	+0.437	+0.067	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106049 vs PLAT — UCEC

Explore this scatter interactively →