Regulation of cellular response to osmotic stress

Across TCGA patient cohorts, RNA activity of the Regulation of cellular response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CA9, LINC02747, and POSTN, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to osmotic stress activity versus CA9 in LUAD (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CA9 →	+1.200	+0.137	.001	.004	3	4
CCRCC	LINC02747 →	-1.614	-0.531	.003	.002	3	4
PDAC	POSTN →	+0.725	+0.112	<.001	.006	3	4
UCEC	HAPLN3 →	+0.943	+0.313	.003	<.001	3	3
UCEC	LINC00683 →	-0.501	-0.227	.006	.007	3	3
LUAD	PDGFRL →	+0.668	+0.226	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106049 vs CA9 — LUAD

Explore this scatter interactively →