Regulation of cellular response to osmotic stress

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STX4, AHDC1, and TRIM47, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, STX4 grouped by Regulation of cellular response to osmotic stress-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	STX4 →	-0.666	-1.015	.001	.001	3	5
LUNG_NSCLC_LUAD	AHDC1 →	-0.784	-0.704	.005	.007	3	4
LUNG_NSCLC_LUAD	TRIM47 →	-0.743	-0.764	.006	<.001	3	4
LUNG_NSCLC_LUSC	SH3RF2 →	-1.997	-1.383	.001	<.001	3	4
LUNG_NSCLC_LUAD	SMIM14 →	-1.175	-0.875	.002	.003	3	4
LUNG_NSCLC_LUAD	IQCD →	-0.831	-0.737	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

STX4 by Regulation of cellular response to osmotic stress activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →