Regulation of cellular response to osmotic stress

Across TCGA cell cohorts, RNA activity of the Regulation of cellular response to osmotic stress pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DIMT1, SPPL2A, and PFDN2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular response to osmotic stress activity versus DIMT1 in BLOOD_Leukemia (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DIMT1 →	+0.705	+0.230	.002	.004	3	6
LUNG_SCLC	SPPL2A →	-1.044	-0.277	<.001	<.001	3	5
STOMACH	PFDN2 →	+1.061	+0.303	.003	.003	3	5
STOMACH	H3C6 →	-1.535	-0.210	.002	.006	3	5
PANCREAS	YWHAE →	+0.876	+0.343	.002	.002	3	4
OVARY	P3H3 →	+3.063	+0.262	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106049 vs DIMT1 — BLOOD_Leukemia

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