Neuron projection organization

Across TCGA patient cohorts, RNA activity of the Neuron projection organization pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SL333P, EP300, and RSKR, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection organization activity versus RN7SL333P in CHOL (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	RN7SL333P →	+1.191	+0.031	<.001	<.001	3	31
ACC	EP300 →	+1.080	+0.022	<.001	<.001	3	31
CHOL	RSKR →	+1.217	+0.043	<.001	<.001	3	31
SCLC	HECTD4 →	+1.038	+0.072	<.001	<.001	3	31
UCS	RBM12B →	+1.036	+0.046	<.001	<.001	3	31
THYM	EBLN2 →	+0.944	+0.037	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106027 vs RN7SL333P — CHOL

Explore this scatter interactively →