Neuron projection organization

Across TCGA patient cohorts, RNA activity of the Neuron projection organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL4, SET_S7, and FGD5_S552, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection organization activity versus RPL4 in GBM (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL4 →	-0.266	-0.041	.005	.002	3	5
OV	SET_S7 →	-0.592	-0.033	.007	.004	2	5
OV	FGD5_S552 →	+1.145	+0.045	<.001	.001	3	4
OV	NAV3_S275 →	+1.219	+0.055	<.001	<.001	3	4
OV	PAK1_S204 →	+0.832	+0.042	<.001	<.001	3	4
OV	PLOD1 →	+0.472	+0.029	.008	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106027 vs RPL4 — GBM

Explore this scatter interactively →