Neuron projection organization

Across TCGA cell cohorts, RNA activity of the Neuron projection organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CRYBG1, LRRC1, and ADGRF4, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection organization activity versus CRYBG1 in URINARY_TRACT (Pearson r = 0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CRYBG1 →	+2.370	+0.127	<.001	<.001	3	9
STOMACH	LRRC1 →	+1.241	+0.115	<.001	.001	3	9
URINARY_TRACT	ADGRF4 →	+1.853	+0.072	<.001	.005	3	9
URINARY_TRACT	MAPK13 →	+2.137	+0.071	.004	.007	3	9
OVARY	GEMIN5 →	-0.977	-0.147	<.001	<.001	3	9
OVARY	BICDL2 →	+2.026	+0.102	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106027 vs CRYBG1 — URINARY_TRACT

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