Neuron projection organization

Across TCGA cell cohorts, RNA activity of the Neuron projection organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA3, SIX5, and SAMD11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuron projection organization activity versus ITGA3 in BLOOD_Leukemia (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ITGA3 →	+1.146	+0.299	<.001	.005	3	4
URINARY_TRACT	SIX5 →	-1.178	-0.349	<.001	.001	3	4
SOFT_TISSUE	SAMD11 →	-3.066	-0.242	.002	.006	3	3
SKIN	CHIC2 →	+0.853	+0.251	.001	.002	3	3
SKIN	GALE →	-0.709	-0.209	.002	.002	3	3
SKIN	BTG2 →	+1.139	+0.211	.004	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106027 vs ITGA3 — BLOOD_Leukemia

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