Negative regulation of inflammatory response to wounding

Across TCGA patient cohorts, RNA activity of the Negative regulation of inflammatory response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEC24AP1, LINC02033, and TMEM106B, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inflammatory response to wounding activity versus SEC24AP1 in LUAD (Pearson r = 0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SEC24AP1 →	+0.360	+0.293	.009	.001	3	3
LUAD	LINC02033 →	+0.258	+0.325	.004	.007	3	3
GBM	TMEM106B →	+0.336	+0.129	.005	.006	3	2
GBM	LNPEP →	+0.314	+0.182	.004	.005	3	2
GBM	RNF6 →	+0.193	+0.132	.008	.005	3	2
GBM	EDA2R →	+1.099	+0.212	.001	.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106015 vs SEC24AP1 — LUAD

Explore this scatter interactively →