Negative regulation of inflammatory response to wounding

Across TCGA cell cohorts, RNA activity of the Negative regulation of inflammatory response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DSG2, BIK, and GJB3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of inflammatory response to wounding activity versus DSG2 in URINARY_TRACT (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DSG2 →	+3.453	+2.142	.001	<.001	3	7
OVARY	BIK →	+2.141	+1.499	.001	<.001	3	5
LUNG_NSCLC_LUAD	GJB3 →	+2.450	+1.153	.001	<.001	3	5
LUNG_NSCLC_LUAD	UMAD1 →	-0.915	-1.172	.001	<.001	3	5
BLOOD_Leukemia	PAIP2 →	-0.721	-0.773	<.001	<.001	3	5
STOMACH	ABHD17B →	-0.842	-1.076	.002	.007	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106015 vs DSG2 — URINARY_TRACT

Explore this scatter interactively →