Regulation of inflammatory response to wounding

Across TCGA patient cohorts, RNA activity of the Regulation of inflammatory response to wounding pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMNL1, ARHGAP45, and HMG20A_S105, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inflammatory response to wounding activity versus FMNL1 in GBM (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FMNL1 →	+0.701	+0.188	<.001	<.001	3	9
GBM	ARHGAP45 →	+0.619	+0.134	<.001	<.001	3	9
PDAC	HMG20A_S105 →	-0.684	-0.049	<.001	<.001	3	9
OV	ANKRD44 →	+0.457	+0.063	.003	.003	3	9
GBM	TBC1D2B →	+0.329	+0.156	<.001	<.001	3	8
GBM	WAS →	+0.686	+0.175	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106014 vs FMNL1 — GBM

Explore this scatter interactively →