Regulation of inflammatory response to wounding

Across TCGA cell cohorts, RNA activity of the Regulation of inflammatory response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZSCAN32, SPAST, and SMCO1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZSCAN32 grouped by Regulation of inflammatory response to wounding-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZSCAN32 →	+1.046	+1.696	.004	<.001	3	5
LUNG_NSCLC_LUSC	SPAST →	+0.928	+1.013	.002	.007	3	4
UPPER_AERODIGESTIVE_TRACT	SMCO1 →	+0.041	+1.315	.006	.007	3	3
CNS	CLDND2 →	-0.515	-1.082	.008	.002	3	3
BONE	SLC25A14 →	-0.822	-1.861	.002	<.001	3	3
BONE	ZNF227 →	+0.694	+1.401	.006	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZSCAN32 by Regulation of inflammatory response to wounding activity — BLOOD_Lymphoma

Explore this box plot interactively →