Regulation of inflammatory response to wounding

Across TCGA cell cohorts, RNA activity of the Regulation of inflammatory response to wounding pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIBCH, LAMA3, and RARS2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of inflammatory response to wounding activity versus HIBCH in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	HIBCH →	-1.154	-0.267	<.001	.004	3	6
PANCREAS	LAMA3 →	+4.215	+1.528	<.001	<.001	3	6
LUNG_SCLC	RARS2 →	-0.682	-1.042	.001	.007	3	6
URINARY_TRACT	MST1R →	+3.408	+1.364	.001	.006	3	6
UPPER_AERODIGESTIVE_TRACT	ZMYM4 →	-0.813	-0.206	.001	.001	2	6
PANCREAS	PDXP →	-1.320	-1.526	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106014 vs HIBCH — UPPER_AERODIGESTIVE_TRACT

Explore this scatter interactively →