Intestinal hexose absorption

Across TCGA patient cohorts, RNA activity of the Intestinal hexose absorption pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PLS1, C1QC, and MISP3_S91, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal hexose absorption activity versus PLS1 in HNSC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PLS1 →	+0.720	+0.139	<.001	<.001	3	8
COAD	C1QC →	-0.543	-0.066	<.001	<.001	3	6
UCEC	MISP3_S91 →	+0.740	+0.102	<.001	<.001	3	6
GBM	PARP4 →	+0.510	+0.200	<.001	<.001	3	6
BRCA	FAM83H_S892 →	+0.764	+0.068	<.001	.001	3	5
BRCA	GRB7 →	+0.561	+0.043	.005	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106001 vs PLS1 — HNSC

Explore this scatter interactively →