Intestinal hexose absorption

Across TCGA patient cohorts, RNA activity of the Intestinal hexose absorption pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EZR, EGOT, and PLS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal hexose absorption activity versus EZR in LUAD (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EZR →	+0.672	+0.226	<.001	<.001	3	5
CCRCC	EGOT →	+0.993	+0.327	<.001	<.001	3	3
UCEC	PLS1 →	+0.666	+0.305	<.001	.003	3	3
UCEC	ATP8B2 →	-0.559	-0.316	.002	.007	3	3
UCEC	CLDN12 →	+0.347	+0.266	.001	.004	3	3
UCEC	AXL →	-0.613	-0.297	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106001 vs EZR — LUAD

Explore this scatter interactively →