Intestinal hexose absorption

Across TCGA cell cohorts, RNA activity of the Intestinal hexose absorption pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VIL1, PPFIBP2, and CCL15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal hexose absorption activity versus VIL1 in LARGE_INTESTINE (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VIL1 →	+3.873	+0.355	<.001	<.001	3	5
LIVER	PPFIBP2 →	+3.206	+0.342	.009	.004	3	5
LARGE_INTESTINE	CCL15 →	+2.792	+0.396	<.001	<.001	3	5
OESOPHAGUS	ARSK →	-1.765	-0.596	.009	.002	3	4
STOMACH	KATNAL1 →	-2.005	-0.462	.002	.002	3	4
STOMACH	KLHL5 →	-2.711	-0.437	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0106001 vs VIL1 — LARGE_INTESTINE

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