Neurotransmitter receptor localization to postsynaptic specialization membrane

Across TCGA cell cohorts, RNA activity of the Neurotransmitter receptor localization to postsynaptic specialization membrane pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCUR1, ANTXR2, and SLC35B3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter receptor localization to postsynaptic specialization membrane activity versus MCUR1 in BLOOD_Myeloma (Pearson r = -0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MCUR1 →	-0.378	-1.635	.007	.002	3	5
KIDNEY	ANTXR2 →	-1.909	-0.364	.001	.002	3	4
STOMACH	SLC35B3 →	-0.991	-1.582	.001	<.001	3	4
BLOOD_Leukemia	CASK →	+1.834	+1.236	<.001	<.001	3	4
STOMACH	CEP55 →	-2.009	-2.032	.003	<.001	3	4
URINARY_TRACT	TLE5 →	+0.844	+1.384	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099645 vs MCUR1 — BLOOD_Myeloma

Explore this scatter interactively →