Endosome to plasma membrane protein transport

Across TCGA patient cohorts, RNA activity of the Endosome to plasma membrane protein transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are S100A2, UNC93B1, and WIPF1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome to plasma membrane protein transport activity versus S100A2 in BRCA (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	S100A2 →	-1.462	-0.033	<.001	.001	3	4
LSCC	UNC93B1 →	-0.291	-0.051	.003	<.001	3	4
OV	WIPF1 →	-0.292	-0.030	.003	.007	3	4
OV	ICAM1 →	-0.526	-0.048	.001	<.001	3	4
LUAD	AKAP9_S3842 →	+0.340	+0.039	.003	.001	3	4
GBM	MRTFA_S385 →	+0.332	+0.051	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099638 vs S100A2 — BRCA

Explore this scatter interactively →