Endosome to plasma membrane protein transport

Across TCGA patient cohorts, RNA activity of the Endosome to plasma membrane protein transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C10orf82, KRT8, and C8orf33, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome to plasma membrane protein transport activity versus C10orf82 in UCEC (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C10orf82 →	+0.884	+0.561	.001	.001	3	4
UCEC	KRT8 →	+1.117	+0.355	.001	.008	3	4
BRCA	C8orf33 →	+0.423	+0.572	<.001	<.001	3	4
BRCA	NDUFB9 →	+0.407	+0.645	.009	.001	3	4
BRCA	COMMD5 →	+0.690	+1.072	<.001	<.001	3	4
BRCA	PUF60 →	+0.686	+1.001	.002	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099638 vs C10orf82 — UCEC

Explore this scatter interactively →