Endosome to plasma membrane protein transport

Across TCGA cell cohorts, RNA activity of the Endosome to plasma membrane protein transport pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEPTIN3, PEA15, and NIBAN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Endosome to plasma membrane protein transport activity versus SEPTIN3 in SOFT_TISSUE (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SEPTIN3 →	-2.612	-0.211	<.001	.003	3	5
LIVER	PEA15 →	+1.493	+0.233	<.001	.001	3	5
BLOOD_Leukemia	NIBAN2 →	+1.899	+0.168	<.001	.001	3	5
LIVER	UBTD1 →	+1.611	+0.207	.003	.002	3	5
SOFT_TISSUE	NRP1 →	+4.117	+0.291	.004	.001	3	5
SOFT_TISSUE	SP140 →	+1.829	+0.253	.007	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099638 vs SEPTIN3 — SOFT_TISSUE

Explore this scatter interactively →