Neurotransmitter receptor transport

Across TCGA patient cohorts, RNA activity of the Neurotransmitter receptor transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC1A1, HDLBP, and IKBIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter receptor transport activity versus SLC1A1 in BRCA (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC1A1 →	+0.927	+0.042	<.001	<.001	3	5
OV	HDLBP →	-0.213	-0.031	<.001	.001	3	5
OV	IKBIP →	-0.327	-0.033	.007	.006	3	5
OV	HOOK2 →	+0.379	+0.037	.003	.003	3	5
BRCA	NFIA →	+0.350	+0.042	.008	.003	3	5
OV	GFPT2 →	-0.777	-0.038	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099637 vs SLC1A1 — BRCA

Explore this scatter interactively →