Neurotransmitter receptor transport

Across TCGA cell cohorts, RNA activity of the Neurotransmitter receptor transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL23, MRPS9, and AIF1L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL23 grouped by Neurotransmitter receptor transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RPL23 →	+0.702	+0.793	.005	.008	3	4
BLOOD_Leukemia	MRPS9 →	+0.691	+1.264	.001	.001	3	4
LUNG_NSCLC_LUAD	AIF1L →	+1.380	+0.640	.004	.007	3	4
LIVER	C1QL1 →	-3.531	-1.520	<.001	.008	2	4
LIVER	ELANE →	-0.173	-1.466	.003	<.001	3	3
BLOOD_Leukemia	HSP90AB1 →	+0.751	+1.370	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL23 by Neurotransmitter receptor transport activity — LUNG_SCLC

Explore this box plot interactively →