Neurotransmitter receptor transport

Across TCGA cell cohorts, RNA activity of the Neurotransmitter receptor transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ROPN1L, CYP27C1, and ZNRD2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neurotransmitter receptor transport activity versus ROPN1L in LUNG_NSCLC_LUAD (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ROPN1L →	+0.869	+0.199	<.001	.002	3	4
OESOPHAGUS	CYP27C1 →	-1.549	-0.226	.003	.001	3	4
BLOOD_Leukemia	ZNRD2 →	-0.421	-0.218	.008	<.001	3	4
STOMACH	AKAP11 →	+0.975	+0.232	<.001	.001	3	4
STOMACH	SLC39A9 →	+0.574	+0.236	.001	<.001	3	4
STOMACH	MECOM →	+2.071	+0.215	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099637 vs ROPN1L — LUNG_NSCLC_LUAD

Explore this scatter interactively →