Ventricular cardiac muscle cell membrane repolarization

Across TCGA patient cohorts, RNA activity of the Ventricular cardiac muscle cell membrane repolarization pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADH1B, ABCC8, and ERO1A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ventricular cardiac muscle cell membrane repolarization activity versus ADH1B in LUAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ADH1B →	+1.571	+0.465	<.001	.005	3	7
GBM	ABCC8 →	+1.109	+0.910	<.001	<.001	3	7
UCEC	ERO1A →	-0.909	-0.588	<.001	.001	3	6
PDAC	ACKR1 →	+1.115	+0.335	.002	.009	3	6
LSCC	ZBTB16 →	+0.952	+0.339	<.001	<.001	3	5
LUAD	SLC2A1 →	-1.411	-0.461	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099625 vs ADH1B — LUAD

Explore this scatter interactively →