Atrial cardiac muscle cell membrane repolarization

Across TCGA cell cohorts, RNA activity of the Atrial cardiac muscle cell membrane repolarization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRN, HES6, and ACTN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SPRN grouped by Atrial cardiac muscle cell membrane repolarization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SPRN →	+0.663	+1.625	.001	.002	3	5
SKIN	HES6 →	+2.069	+0.995	<.001	<.001	3	5
URINARY_TRACT	ACTN1 →	-1.352	-2.154	<.001	<.001	3	4
BONE	NDRG1 →	-3.757	-1.422	<.001	.002	2	5
BONE	SERINC3 →	-1.070	-1.782	.008	.005	3	4
CNS	NT5E →	-3.525	-1.125	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SPRN by Atrial cardiac muscle cell membrane repolarization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →