Atrial cardiac muscle cell membrane repolarization

Across TCGA cell cohorts, RNA activity of the Atrial cardiac muscle cell membrane repolarization pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BLVRA, HACD3, and C5AR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BLVRA grouped by Atrial cardiac muscle cell membrane repolarization-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	BLVRA →	+0.325	+0.233	<.001	.002	3	5
BLOOD_Leukemia	HACD3 →	+0.216	+1.456	.001	.003	3	5
UPPER_AERODIGESTIVE_TRACT	C5AR1 →	-0.114	-0.265	.001	<.001	3	5
BLOOD_Leukemia	SYNCRIP →	+0.256	+1.312	.001	<.001	3	4
STOMACH	PIKFYVE →	+0.231	+1.731	.007	<.001	3	4
BLOOD_Myeloma	LPCAT2 →	+0.233	+1.453	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BLVRA by Atrial cardiac muscle cell membrane repolarization activity — KIDNEY

Explore this box plot interactively →