Regulation of cardiac muscle cell membrane repolarization

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle cell membrane repolarization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEPTIN4_S325, HAT1, and IGFBP7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle cell membrane repolarization activity versus SEPTIN4_S325 in COAD (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SEPTIN4_S325 →	+0.511	+0.034	<.001	.002	3	8
UCEC	HAT1 →	-0.423	-0.048	<.001	<.001	3	8
PDAC	IGFBP7 →	+0.565	+0.041	<.001	.003	3	8
LSCC	NAT10 →	-0.380	-0.047	<.001	<.001	3	8
CCRCC	PBX1 →	+0.736	+0.076	<.001	<.001	3	8
UCEC	PRKG1 →	+0.757	+0.055	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099623 vs SEPTIN4_S325 — COAD

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