Regulation of cardiac muscle cell membrane repolarization

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle cell membrane repolarization pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIG1, DDB1, and TBC1D9B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AIG1 grouped by Regulation of cardiac muscle cell membrane repolarization-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	AIG1 →	+0.328	+0.212	.001	.007	3	4
BLOOD_Leukemia	DDB1 →	+0.570	+0.363	<.001	.001	3	4
LIVER	TBC1D9B →	+0.383	+0.096	.003	.004	2	4
KIDNEY	CDK13 →	-0.223	-0.212	<.001	.007	3	3
SKIN	CTSL →	-0.178	-0.181	<.001	.001	3	3
SKIN	GLMN →	-0.305	-0.209	.007	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AIG1 by Regulation of cardiac muscle cell membrane repolarization activity — KIDNEY

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