Protein localization to axon

Across TCGA patient cohorts, RNA activity of the Protein localization to axon pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, MCCC1, and CD276, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to axon activity versus UCHL1 in HNSC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UCHL1 →	+1.354	+0.116	<.001	<.001	3	5
HNSC	MCCC1 →	+0.427	+0.093	<.001	<.001	3	5
LUAD	CD276 →	-0.298	-0.064	.003	<.001	3	5
GBM	MMP14 →	-0.397	-0.106	<.001	<.001	3	5
GBM	DNAJC10 →	-0.307	-0.151	<.001	<.001	3	5
GBM	RPL15 →	-0.494	-0.192	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099612 vs UCHL1 — HNSC

Explore this scatter interactively →