Protein localization to axon

Across TCGA cell cohorts, RNA activity of the Protein localization to axon pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C11orf98, DCAF13, and PUF60, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C11orf98 grouped by Protein localization to axon-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C11orf98 →	-0.481	-1.044	.006	.001	3	5
UPPER_AERODIGESTIVE_TRACT	DCAF13 →	-0.912	-1.373	.003	<.001	3	4
BLOOD_Myeloma	PUF60 →	-1.407	-1.883	.002	<.001	3	4
LIVER	TSHZ1 →	-1.343	-1.596	.007	.001	3	4
LUNG_NSCLC_LUSC	PROB1 →	-0.972	-1.435	<.001	.008	2	5
STOMACH	PRR3 →	-0.945	-1.674	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C11orf98 by Protein localization to axon activity — BLOOD_Leukemia

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