Protein localization to axon

Across TCGA cell cohorts, RNA activity of the Protein localization to axon pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RCE1, SLC25A53, and FRY, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RCE1 grouped by Protein localization to axon-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RCE1 →	-0.250	-2.014	.007	.001	3	2
LUNG_SCLC	SLC25A53 →	+0.340	+1.772	<.001	<.001	3	2
SKIN	FRY →	+0.160	+1.857	.005	.002	3	2
LUNG_SCLC	SEPTIN3 →	+0.235	+1.772	.007	<.001	3	1
LUNG_SCLC	LRRC74A →	+0.207	+1.772	.005	<.001	3	1
LUNG_SCLC	TSC2 →	+0.248	+1.772	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RCE1 by Protein localization to axon activity — LUNG_SCLC

Explore this box plot interactively →