Regulation of neurotransmitter receptor activity

Across TCGA patient cohorts, RNA activity of the Regulation of neurotransmitter receptor activity pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STK10, BIN2, and DLGAP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter receptor activity activity versus STK10 in CCRCC (Pearson r = 0.00).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	STK10 →	+0.181	+0.032	.004	.001	3	5
CCRCC	BIN2 →	+0.331	+0.037	<.001	<.001	3	5
HNSC	DLGAP4 →	+0.434	+0.064	<.001	<.001	3	5
HNSC	GBP5 →	+0.944	+0.082	<.001	<.001	3	5
CCRCC	ARHGAP9 →	+0.300	+0.031	<.001	<.001	3	5
CCRCC	PSTPIP1 →	+0.543	+0.055	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099601 vs STK10 — CCRCC

Explore this scatter interactively →