Regulation of neurotransmitter receptor activity

Across TCGA patient cohorts, RNA activity of the Regulation of neurotransmitter receptor activity pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R16B, CCDC69, and DENR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neurotransmitter receptor activity activity versus PPP1R16B in GBM (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PPP1R16B →	+1.500	+0.902	<.001	<.001	3	6
LSCC	CCDC69 →	+0.702	+0.386	<.001	<.001	3	6
LSCC	DENR →	-0.417	-0.400	<.001	<.001	3	5
CCRCC	KCNN3 →	+1.081	+0.770	<.001	<.001	3	5
LSCC	ASF1B →	-0.795	-0.470	<.001	<.001	3	5
LSCC	LTBR →	-0.470	-0.401	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099601 vs PPP1R16B — GBM

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